Antivirals Ingredients Ribavirin Chemical Inhibitors
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Description
Product Name: Ribavirin
Synonyms: REBETOL;RIBAVIRIN;rtca;tribavirin;vilona;VIRAMID;VIRAZID;VIRAZOLE
CAS: 36791-04-5
MF: C8H12N4O5
MW: 244.2
EINECS: 1308068-626-2
Melting point 174-176°C
alpha D25 -36.5° (c = 1 in water); D20 -38° (c = 1 in water)
refractive index -36 ° (C=1, H2O)
storage temp. 2-8°C
Water Solubility >=10 g/100 mL at 19 ºC
Merck 14,8198
Descriptions:
Ribavirin is a novel non-selective nucleoside class broad-spectrum antiviral drug, belonging to the inosine monophosphate (IMP) dehydrogenase inhibitor. It can participate in the guanine participate in the human body metabolism, interfere with the biosynthesis of guanine, prevent the replication of the virus and has inhibitory effect on a variety of DNA and RNA viruses. Ribavirin has a stronger antiviral effect than amantadine and vidarabine, etc with definite efficacy and small drug side effects. Rare adverse reactions include conjunctivitis and hypotension with the former exhibiting as intraocular foreign body sensation, photophobia, itching, swelling and hematoma and the latter manifested as blurred vision, dizziness, and fatigue. It is used for clinical treatment of viral upper respiratory tract infection, respiratory syncytial virus-induced viral pneumonia and bronchitis, influenza, para-influenza, epidemic encephalris, mumps, chickenpox, shingles, herpes zoster, autumn diarrhea, children early-stage adenovirus pneumonia, acute Lassa fever, rubella, viral pneumonia, genital herpes, herpes simplex virus keratitis, psoriasis, etc with special efficacy. It also have certain efficacy on treating epidemic hemorrhagic fever, hepatitis B, and hepatitis A. Applying this drug in early stage of epidemic hemorrhagic fever can shorten the period, reducing the damage of kidney and vascular and symptoms of poisoning.
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