Local Anesthesia Raws Tetracaine Hydrochloride
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Description
Tetracaine Local Anesthesia Powder Tetracaine Hydrochloride CAS 136-47-0
Product Name: Tetracaine hydrochloride
Synonyms: L AND OCAIN HYDROCHLORIDE;INTERCAIN HYDROCHLORIDE;MEETHOBALM HYDROCHLORIDE;2-(DIMETHYLAMINO)ETHYL 4-(N-BUTYLAMINO)BENZOATE HYDROCHLORIDE;2-DIMETHYLAMINOETHYL ESTER OFP-BUTYLAMINOBENZOIC ACID HYDROCHLORIDE;4-(N-BUTYLAMINO)BENZOIC ACID 2-(DIMETHYLAMINO)ETHYL ESTER HYDROCHLORIDE
CAS: 136-47-0
MF: C15H25ClN2O2
MW: 300.82
EINECS: 205-248-5
Chemical Properties White Solid
Usage anesthetic (local)
Tetracaine Hydrochloride Medical uses
A systematic review investigated tetracaine for use in emergency departments, especially for starting intravenous lines in children, in view of its analgesic and cost-saving properties. However, it did not find an improvement in first-attempt cannulations.
Tetracaine is the T in TAC, a mixture of 5 to 12% tetracaine, 0.05% adrenaline, and 4 or 10% cocaine hydrochloride used in ear, nose, and throat surgery and in the emergency department where numbing of the surface is needed rapidly, especially when children have been injured in the eye, ear, or other sensitive locations.
Tetracaine Application
1) In biomedical research, tetracaine is used to alter the function of the calcium release pathway (Lannottine receptor), which controls intracellular stores to release calcium. Dicaine is an allosteric blocker for channel function. At low concentrations, tetracaine causes initial inhibition of spontaneous calcium release events, whereas at high concentrations, tetracaine is completely released.
2) tetrabinocaine is synthesized from 4-butylaminobenzoic acid. The esterification reaction is carried out by acid catalysis to form ethyl ester. The base-catalyzed transesterification is achieved by boiling ethyl 4-butylaminobenzoic acid with an excess of 2-dimethylaminoethanol in the presence of a small amount of sodium ethoxide.
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